Table 1

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Table I. Parameter estimates from segregation analysis
of prostate cancer in 1199 families ascertained through a single prostate cancer proband

Hypothesis

-2 in L

X²

P Value

ßAA

ßAB

ßBB

No major gene Dominant
Codominant
Recessive
Environmental General

2803.10
2777.66
2780.66
2798.84
2782.26
2773.92

6
4
3
4
2
-

29.18
3.74
6.74
24.92
8.34
-

<0.001
0.43
0.23
0.001
0.015
-

[1.0]
0.0037
0.0265
0.761
0.619
0.662

-
[1.0]
[1.0]
[1.0]
0.441
1

-
[0.5]
[0.5]
[0.5]
=

AA
0.43

-
[0.0]
[0.0]
[0.0]
=

AA
0

-49.35
-51.49
-26.73
-66.93
-59.23
-92.60

=ßAA
=ßAA
-66.39
-49.38
-83.23
-94.17

=ßAA
-57.15
-70.05
=ßAB
-56.09
-50.62

0.17
0.178
0.237
0.171
0.196
0.174

0.36
1.0
0.41
0.56
1.0
1.0

Key: df = degrees of freedom; q = frequency of putative high-risk allele;

= transmission parameter denoting the probability that a parent of a given type transmits the disease-producing factor A to his or her offspring; ß = baseline parameter; a = age adjustment parameter; y = susceptibility parameter describing the cumulative probability of prostate cancer (assuming an infinite lifespan).
Numbers in brackets are fixed at the indicated value.
Chi-square (X²) defined as (-2 In L) of the data under the hypothesis minus (-2 In L) of the data under the general model.

Figure 1	Return to article
Figure 1. Predicted cumulative risks for types AA/AB (carriers of the high-risk allele) and BB (noncarriers) genotypes. Dotted lines represent data from Carter et al. ² (the John Hopkins [JHU] study).