QUEST informs readers of the latest advances in urologic prostate cancer research, especially detection, prevention, and treatment.
The committee’s panel members were not concerned with the effectiveness of the oral testosterone treatment. Rather, they cited concerns over potential cardiovascular risks. In trials for both Jatenzo and Tlando, patients had upward shifts in blood pressure as measured by…
Apalutamide Reduces Risk of Metastatic Cancer, Receives FDA Approval Apalutamide (brand name Erleada) is an oral drug that blocks the effect of androgens, a group of hormones, on prostate tumors. These androgens, such as testosterone, can promote tumor growth. In…
Abiraterone (brand name Zytiga) is an oral drug that interrupts androgen production in the testes, the adrenal glands, and in prostate tumors. Abiraterone is taken in combination with the steroid prednisone. The LATITUDE trial assessed the use of abiraterone for…
Ongoing research continues to assess the criteria used to select patients for active surveillance. Clinical guidelines currently recommend active surveillance for men diagnosed with very low-risk and low-risk prostate cancer. Guidelines also state that men with low-volume intermediate risk disease…
Astudy of 100 prostate cancer patients in New Zealand and Australia looked at the effect of an exercise program on men who had short-term or long-term ADT in combination with radiation. The patients were randomly assigned to either an exercise…
Biochemical recurrence was defined as two consecutive PSA measurements of at least 0.2 ng/mL after the patient’s radical prostatectomy. The authors of the study used a long-term follow-up and analyzed several data points for 1,100 patients who underwent radical prostatectomy…
A study in Spain found that men who ate a Mediterranean-style diet rich in fruits, vegetables, fish, legumes and olive oil were less likely to develop aggressive prostate cancer. The study looked at three dietary patterns: the Western, Prudent, and…
Earlier research has found a connection between advanced prostate cancer and high cholesterol, but the reason for the connection has not been clear. Recently, researchers at the Duke Cancer Institute have identified a process that cancer cells use to hoard…
The researchers were particularly interested in how the cancer cells change when the disease metastasizes, since this is when prostate cancer can become lethal. Genetic studies have shown that the loss of PTEN, a tumor suppressor gene, is involved in…
Unlike many other men, Steven Denny’s prostate cancer diagnosis didn’t begin with his PSA test. Instead, it started with a kidney stone that landed him in the emergency room. Although the doctors advised Steven that the stone would pass in…
