Astudy in Australia found that obese men with a BMI of 30 or higher had lower concentrations of PSA in their blood when compared to men with normal weights. The authors said that the lower PSA levels could be an effect of obese men having lower concentrations of circulating testosterone, as PSA is increased by testosterone. "The results of this study have important implications for how we should interpret PSA levels in men who are obese," said project supervisor Professor Gary Wittert of the Adelaide Medical School at the University of Adelaide.
Future studies are needed to determine how to apply this knowledge in clinical practice. The study included 970 Australian men and was published in the Society for Endocrinology.