QUEST informs readers of the latest advances in urologic prostate cancer research, especially detection, prevention, and treatment.

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Decline in PSA levels is associated with improved survival

Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) is inceasingly included in the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC).  In this analysis, 184 patients were treated with 177Lu-PSMA RLT. Response to treatment was defined as decrease in PSA…

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A more robust follow-up protocol may be necessary for some men

There is no standard follow-up protocol for men with a negative evaluation with systematic biopsies and multiparametric MRI (mpMRI) and a persistent clinical suspicion of prostate cancer. This study assessed the proportion of clinically significant prostate cancers during follow-up after…

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Maximum tumor diameter provides information before treatment

Maximum tumor diameter on pretreatment MRI has the potential to provide further information to men with prostate cancer before definitive treatment. This retrospective analysis included a cohort of 631 patients. Analysis identified 4 prognostic groups for patients treated with radical…

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Efficacy of PSMA-radioguided surgery

In this phase II trial, the authors investigated the efficacy of prostate-specific membrane antigen (PSMA)-radioguided surgery in identifying lymph node invasion during robot-assisted radical prostatectomy in patients with clinically-localized prostate cancer. Overall, 12 patients with intermediate-or high-risk prostate cancer underwent…

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