QUEST informs readers of the latest advances in urologic prostate cancer research, especially detection, prevention, and treatment.

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Refining prostate cancer screening

Screening for prostate cancer is burdened by a high rate of overdiagnosis. The most appropriate algorithm for population- based screening is unknown. This study invited 37,887 men who were 50-60 years of age to undergo regular PSA screening. Participants with…

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By the Numbers – 2023

Each year, the American Cancer Society estimates the number of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes. In 2023, 1,958,310 new cancer cases and 609,820 cancer…

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Decline in PSA levels is associated with improved survival

Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) is inceasingly included in the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC).  In this analysis, 184 patients were treated with 177Lu-PSMA RLT. Response to treatment was defined as decrease in PSA…

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A more robust follow-up protocol may be necessary for some men

There is no standard follow-up protocol for men with a negative evaluation with systematic biopsies and multiparametric MRI (mpMRI) and a persistent clinical suspicion of prostate cancer. This study assessed the proportion of clinically significant prostate cancers during follow-up after…

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