Higher Risk of Bladder Cancer After Radiation Therapy

Categories: Winter 2018
According to a new analysis, patients with clinically-localized prostate cancer who were treated with external beam radiation therapy had a higher risk of later developing bladder cancer when compared to patients who had a radical prostatectomy.

The study used data on 84,397 men. Radiation therapy patients had higher rates of developing bladder cancer. After 5 years, 1.26% of patients who underwent radiation developed bladder cancer, compared to 0.75% of men who had radical prostatectomies. After 10 years, the rates of bladder cancer were 2.34% and 1.63% for men who had radiation or a prostatectomy, respectively.

When accounting for multiple variables, the researchers estimated that radiation therapy for localized prostate cancer was associated with a 35%increased risk of bladder cancer compared to radical prostatectomy. The authors suggested that patients with localized prostate cancer should be counseled regarding this risk when they make a decision regarding treatment. They also suggested that a randomized prospective trial is needed to confirm their findings.

The study was published online ahead of print in European Urology in October.

Subscribe to Quest

Dr. Catalona Pic With Donate Now Button