QUEST informs readers of the latest advances in urologic prostate cancer research, especially detection, prevention, and treatment.
This study looked at the effectiveness and safety of using MRI screening to detect prostate cancer in men aged 50-60. Researchers divided participants into two groups: one had systematic biopsies (where the prostate gland is charted into six regions and…
A recent article published in the Journal of the American Medical Association, Oncology (JAMA Oncol) included a report on the role of diet in men with low-risk prostate cancer. Dr. Stephen DeVries, a preventive cardiologist and Executive Director of the…
The study investigated how body mass index (BMI) relates to prostate cancer screening results, incidence, and mortality among men participating in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. This trial included 36,756 men who were regularly screened…
A recent clinical trial at Memorial Sloan Kettering Cancer Center in New York suggests that specific amounts of exercise before surgery among men with early-stage prostate cancer can improve two biomarkers associated with better outcomes. This study looked at…
The purpose of watchful waiting in prostate cancer is to avoid adverse effects of active treatment in men who are unlikely to experience long-term benefits of radical treatments due to their limited life expectancy. Is watchful waiting an appropriate management…
This study explores the use of active surveillance for patients with low-risk prostate cancer (LRPC) in Northern Italy. Active surveillance is a treatment strategy where patients are closely monitored instead of receiving immediate, aggressive treatment such as surgery or radiation….
In a phase-3 trial called VISION, researchers studied the effects of lutetium-177 [177Lu]Lu-PSMA-617 (vipivotide tetraxetan) in patients with metastatic castration-resistant prostate cancer. This treatment, when added to standard care, improved both radiographic progression-free survival and overall survival. The study also…
This study aimed to find out if prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) can predict cancer progression in patients with low-grade prostate cancer. These patients had been diagnosed with Grade Group (GG) 1 prostate cancer through…
In the context of prostate cancer management, the standard practice of performing bilateral extended pelvic lymph node dissection (PLND) during radical prostatectomy is being questioned with advancements in imaging technology. Magnetic resonance imaging (MRI)-targeted biopsies now provide more accurate staging,…
A recent study led by Burcu F Darst, PhD (University of Washington and Fred Hutchinson Cancer Research Center) investigated the connection between specific genes and the development of aggressive prostate cancer. Gene testing is currently recommended for men who have…
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