|Being Overweight Can Affect Prostate Cancer Aggressiveness
(This information is an adapted version for Quest readers of a medical journal article written by Stacy Loeb, MD; Xiaoying Yu, MD; Robert B. Nadler, MD; Kimberly A. Roehl; Misop Han, MD; Sheila A. Hawkins, MD; and William J. Catalona, MD)
|Weight, especially being overweight, is a sensitive topic on its own. Studying whether or not weight – in this case Body Mass Index * – affects or can predict outcomes after radical prostatectomy could be an uncomfortable topic to discuss with patients.
But since men can’t change weight after the fact, it is important for them to know beforehand that obesity can affect prostate cancer treatment outcomes.
Prostate cancer researchers are spending a good amount of time taking a look at the relationship of Body Mass Index (BMI) to preoperative PSA velocity and to adverse tumor features in men treated with RRP.
The final verdict is not in yet, but present study results increasingly conclude that being overweight, and especially obese, may be related to increased risks of cancer recurrence.
Relationship Between Weight and Outcomes
We studied the relationship between weight and prostate cancer outcomes. Specifically, we examined the relationships among BMI, PSA Velocity and tumor features in 587 patients who underwent RRP by Dr. William J. Catalona for clinically localized prostate cancer. We compared men with a body mass index of less than 25, 25-29.9 and 30 or greater.
The reasons for the connection between weight and prostate cancer are still under investigation.
*Body mass index (BMI) is a measure of body fat based on height and weight that applies to both adult men and women. You can go a page from the website of the National Institutes of Health www.nhibisupport.com/bmi/ and compute your own BMI.