Outcomes fifteen years after monitoring, surgery, or radiotherapy for prostate cancer

Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 and 69 years of age received a PSA test. 

After 15 years of follow-up, prostate cancer-specific mortality was low in this cohort of men in the UK with early PSA screening-detected localized prostate cancer regardless of the treatment assigned. The authors concluded that the choice of treatment involves weighing trade-offs between benefits and harms associated with treatments for localized prostate cancer.

N Engl J Med. 2023 Apr 27;388(17):1547-1558. doi: 10.1056/NEJMoa2214122. Epub 2023 Mar 11. PMID: 36912538 DOI: 10.1056/NEJMoa2214122