QUEST informs readers of the latest advances in urologic prostate cancer research, especially detection, prevention, and treatment.
In October 2025, President Joe Biden “rang the bell,” at the University of Pennsylvania Radiation Oncology Clinic, a traditional ceremony when patients complete their course of radiation therapy. On October 11, his office announced that he had been undergoing radiation…
The “RAMPP” Randomized Controlled Trial The “RAMPP” randomized clinical primary prostate cancer tumor in men trial was designed to test whether with low-volume metastatic disease, adding radical prostatectomy to what was then considered the “best systemic (i.e., hormonal and chemotherapy)…
A Systematic Review Researchers from Harvard conducted a comprehensive literature review, including 21 informative studies, to determine whether post-diagnosis dietary patterns, lifestyle scores, and related indices are associated with prostate cancer clinical outcomes to inform evidence-based strategies for survivorship and…
To demonstrate whether Stereotactic Body Radiotherapy (SBRT) is not inferior to conventionally or moderately hypo- fractionated radiotherapy (fewer treatments with more radiation delivered with each treatment) regimens for PSA and/or clinical failurefor localized prostate cancer, researchers undertook a clinical trial,…
Machine learning is a field of artificial intelligence that enables computers to learn from data without being explicitly programmed. It involves developing algorithms that can identify patterns, make predictions, and improve performance over time based on experience. Researchers tested a…
Confirmatory biopsy is recommended for men diagnosed with prostate cancer who are considering active surveillance. Now that MRI-informed biopsy is widely available, is this necessary? In this study, men with Grade Group (GG) 1 prostate cancer at diagnosis underwent MRI…
A liquid biopsy is a specimen from blood, urine, saliva or other body fluids tested as a marker for cancer. Examples include circulating DNA, cell-free DNA, and other biomarkers that are from normal cells or cancer cells that can be…
Kudos to Dan Theodorescu, MD, PhD, Director of the University of Arizona Cancer Center, for being the first urologist to receive an NCI R35 Outstanding Investigator Award (7 years of direct-cost research support at $600,000 per year) for researchers with…
In 2012, when the US Preventive Services Task Force (USPSTF) recommended against PSA screening, Dr. Catalona and colleagues responded in an article titled What the U.S. Preventive Services Task Force Missed in Its Prostate Cancer Screening Recommendation, “The recommendations of…
On August 31, 2025, URF Board Member, William “Bill” J. McKenna, passed away peacefully at his home in Fulton, Maryland. Born in Chicago he served as a Captain in the US Naval Reserves for 22 years. Following his military career,…
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