QUEST informs readers of the latest advances in urologic prostate cancer research, especially detection, prevention, and treatment.
Dr. Catalona and other researchers investigated whether the Prostate Health Index (phi) test improved specificity for detecting clinically significant prostate cancer to help reduce prostate cancer overdiagnosis. The team compared the performance of PSA, percent-free PSA, [-2]proPSA and phi in…
Lynch syndrome is a hereditary disorder caused by germline mutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. Normally, MMR genes repair DNA damage generated during DNA replication. When these genes are mutated, they may fail…
Tests for the early detection of prostate cancer Dr. Catalona was the first to show that the PSA blood test could be used as a first-line screening test for prostate cancer. He directed a PSA-based screening study involving more than…
Fifteen years ago, Steiner went to the Mayo Clinic to get checked for colon cancer. He has a family history of the disease and knew it was important to be checked regularly. The doctors did not find colon cancer, but…
At a public conference on vitamin D sponsored by the National Institutes of Health, Dr. Demetrius Albanes (National Cancer Institute) reported on medical literature suggesting that men with the highest levels of vitamin D may have an increased risk of…
Over-the-counter cold and flu preparations that contain both antihistamines and decongestants can create a “perfect storm” for men with symptomatic benign prostatic hyperplasia (BPH). These products could substantially worsen symptoms of BPH, make it harder to urinate and may trigger…
From 1992-2011, there was a 47% decrease in prostate cancer mortality. Yet, the 2009 and 2012 recommendations from the U.S. Preventive Services Task Force (USPSTF) discouraged the use of PSA testing to screen men for prostate cancer. Now, current research…
During 2014, my colleagues and I have worked enthusiastically to maintain our highly collaborative prostate cancer research program that involves research collaborators from across the country and around the world. Some of our past accomplishments and new initiatives have been…
A 2010 study at the University of Buffalo found that men with prostate cancer had more abnormal colon polyps than men without prostate cancer (48% vs. 30.8%), putting them at higher risk of developing colon cancer.1 An Australian study published…
Post-surgical catheters are an annoying but temporary necessity. A patient shared an innovative technique for keeping his catheter in place during a post- operative visit with Dr. Catalona that I observed. The patient was very active professionally and recreationally. He…
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