Statins and Aggressive Prostate Cancer:

Study Looks for Effects in Caucasian and African American Men

Categories: Winter 2016

Included in AUA Prostate Cancer Update Course*

Statin use has been associated with reduced prostate cancer aggressiveness, but the impact of race on this link is not well understood. New research examined the association between statin use and prostate cancer aggressiveness in Caucasian and African American men. The study also looked for effects of smoking and prostate cancer screening.

The study included 1,930 men with prostate cancer from The North Carolina-Louisiana Prostate Cancer Project, with 344 (18%) men defined as having aggressive disease.

Statin use was associated with a reduced risk of prostate cancer aggressiveness in both races. The inverse association was strongest in men who never smoked. There was a weak inverse association in men who were former smokers, and no association in men who currently smoked.

The study did not find a statistically significant relationship between prostate cancer, statin use, and frequency of screening for prostate cancer.

Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):670-7. doi: 10.1158/1055-9965.EPI-15-0631. Epub 2016 Jan 27.

*Dr. Catalona’s Prostate Cancer Update Course

Dr. Catalona led the Prostate Cancer Update course at the American Urological Association annual meeting. The course highlighted important findings on prostate cancer published during the last year. The topics are wide-ranging. This issue of QUEST covers some of these articles, which we hope will be of interest to our readers.

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